HORDB

ID: hor005691
Uniprot ID: Q9IA10
Protein name: Gonadoliberin-1
Gene name: gnrh1
Organism: Dicentrarchus labrax (European seabass) (Morone labrax)
Family: GnRH family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Dicentrarchus (genus), Moronidae (family), Eupercaria incertae sedis, Eupercaria, Percomorphaceae, Euacanthomorphacea, Acanthomorphata, Ctenosquamata, Eurypterygia, Neoteleostei, Euteleosteomorpha (cohort), Clupeocephala, Osteoglossocephalai, Teleostei (infraclass), Neopterygii (subclass), Actinopteri (class), Actinopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007165 signal transduction
GO CC: GO:0005576 extracellular region; GO:0005615 extracellular space

Sequence: QHWSYGLSPG
Length: 10
Propeptide: MAAQTFALRLLLVGTLLGTLLGQGCCQHWSYGLSPGGKRELDGLSETLGNQIVGSFPHVATPCRVLGCAEESPFPKIYRMKGFLDAVTDRENGNRTYKK
Signal peptide: MAAQTFALRLLLVGTLLGTLLGQGCC
Modification: T1 Pyrrolidone carboxylic acid;T10 Glycine amide
Glycosylation: NA
Mutagenesis: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor005691_AF2.pdb

hor005691_ESM.pdb

Mass:	129192	Formula:	C52H70N14O15
Absent amino acids:	ACDEFIKMNRTV	Common amino acids:	GS
pI:	7.54	Basic residues:	1
Polar residues:	5	Hydrophobic residues:	2
Hydrophobicity:	-91	Boman Index:	-801
Half-Life:	0.8 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	39
Instability Index:	4157	Extinction Coefficient cystines:	6990
Absorbance 280nm:	776.67

PubMed ID: 11086295
Title: Differential expression of three different prepro-GnRH (gonadotrophin-releasing hormone) messengers in the brain of the European sea bass (Dicentrarchus labrax).